She became very neurotic, so many changes in her personality and she became very anxious her first and only dose was in November 2020 she never returned to the special dog that we had and she passed in March 2021 at 8 years old. Just gave 3yr old OES first dose yesterday (her half sister got one too) and today she has uncontrolled urination. But the wandering and "head pressing" it's called, where they just go into the corner or lean against a table leg or the wall. With the March 1 dose, on that day, I noticed him seeming to be very fearful and flinching on several occasions. Update June 7th. She spent 4 nights at the University of Auburn emergency room and vet clinic. I couldnt figure it out until I googled all the medications the vet has prescribed for her then I came across this forum and I am pissed!! Hope your dog is doing well .my dog had clear neurological changes after taking Simparica trio .his tounge just hangs out of his mouth now and that was never the case prior to Simparica,also has tremors and shakes he never previously experienced.also major weight gain even though no increase in diet .i decided to take my pet off of simparico even though the vet strongly engouraged we remain on it even though i explained the symptoms and changes I noticed in my pet ! I have another dog, but gave him Frontline and he's fine. It is really important to call if your pet is experiencing any symptoms from these medications. I also am seeking information as to if there is a class action suit against this company because there should be. Please do NOT try Simparica Trio, I went to the Vets office to pick up Dukes Revolution Heart Worm meds, and they talked me into switching to Simparica Trio, we gave Duke his first dosage on March 1st, March 2nd, he would fall down while walking, he would fall down trying to get up, he's NEVER done this before! I did and they said they are going to report it to the FDA. He licks his lips all the time? Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. Our Pickles died last year after just 3 doses, and our vet basically said we were crazy. I have been feeding her some white rice hoping it improves. Product Details: Simparica Trio Chewables for dogs. The product can be purchased directly from your vet, from your vet's online pharmacy, or through an external online pharmacy with a valid prescription. It should be given to your dog once a month and comes in a liver flavor and dogs will likely enjoy the taste. Im beyond heartbroken, shocked, and sad. We were told the Neurologist would be between $10,000 to $12,000. He is acting very skittish/scared like behavior, wants to just lay down. No running or jumping, Continuously wandering around the fence line of the back yard. Omg my girl goes threw incredible itching this has lead to us takeing her to the vet because she gets infected from scratching herself to death. Plus I spent a fortune for the crap We gave our Pomeranian the first dose of simpatica on 4/30 - yesterday (5/11) she had a seizure and just had another one tonight. If anyone has suggestions or knows how else I can help my little guy please let me know. She had terrible vomiting and diarrhea for a week and also weakness and staggering three weeks later. About 11 months ago our vet recommended Simparica Trio. What kind of supplements are you giving her? He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. It may or may not be the cause but I need to do everything in my power to bring my dog back to health. I called the maker of Simparica and filed an FDA case for my dog and told them all of the symptoms she was having from this medicine. RELATED: What You Need to Know About the Lyme Vaccine for Dogs. He had no medical problems before this, and I took him to the vet every year he ended up dying two weeks later , I took him to the vet first they told me he wasnt gonna make it to leave him there and I told him no if he isnt gonna make it, hes going to pass away in my arms at home with me and his family why took him to a different vet not the same one I confronted the woman that gave me that medicine. This went on for 4 hours. I gave simparica trio to my 10-year-old Havanese. If most side effects are mild, ( vomiting 12 hours later could be due to other things the dog has eaten within those 12 hours), I am ok with that. Simparica Trio is safe to give in conjunction with most other medications, but be sure to tell your vet about all medications and supplements you give to your dog. She falls when she runs and when going up and down stairs. But now I tell everyone just be aware that this product does have the potential to cause neurological harm. These are the side effects that were observed: Most common is vomitting Weakness and lethargy Soft stools Loss of appetite I say yes! Not grass grazing either. Simparica, Nexgard, Bravecto and Credelio are part of a group called Isoxazoline drugs. We took him to a emergency Vet Hospital that pin pointed Simparica Trio as the main facture that triggered his controlled seizure episodes in having constant all day tremors & seizures hurting him to the point of making the decision to put him down or have him continue with the pain until it killed him. Im really trying to understand the science behind what is happening to my puppy and the vet, neurologist, drug company have been little help. Are their enough people to file a class action suit? Gave my 3 month old, 3 pound shih tzu simparica on Sunday night. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. Next she developed severe tremors. its been 2 weeks .We just had a blood draw done again and they are still high. For those who lost their dear companions from this medicine my heart goes out to you all. I am so sad to read what is happening to some pets. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. I called my vet but because of Covid they are so behind in appts and would not see him until a month from then. My vet gave us Simparica for my newly adopted Chihuahua yesterday. CET HEXtra Chews. After seeing his condition worsen, that night we took him to an after hours urgent care. However, some dog parents prefer to use separate products. I was blaming the tremors in his back legs on the fact that he has had both ACLs repaired. The FDA considers this level to be "very rare". She is absolutely miserable and we're hoping she makes it. She was ok for awhile, then she had a seizure and started throwing up all over the house. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. Bentlee has been fine for 12 + hours in the house while I was stuck at work and never a drop of anything in the house. For dogs with a history of seizures: consider carefully. Each month he got sicker and sicker. We took him to the animal er and they checked his vitals and he was fine. He has been on just Simparica with no problems. He wasnt throwing up at all until he received this medication. Took her to her Vet where I was told she had another tremor. Omg Im feeling sick seeing all these bad comments. On August 17th, we had to rush him to the ER because he was not moving. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). I hope for all of you that your pets (loved ones) have improved, I know the feeling of total helplessness to help them and all you can do is wait and hope. Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. I'm so upset. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. I would not recommend giving Simparica to your pets!!!!! As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. She is still eating but she is drinking more water. So we went home with her on steroids and more antibiotics and denamrin for liver. X-rays fine. She also started drinking excessively, and peeing in the house. The personality change is what has me most concerned too. I don't recommend anyone risk their pet's life just to be a little easier having a pill to take. and you expect people to give this to their beloved pets? I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. I read all the above and it makes me sad. I've sent this thread and loads of other information to my vet and zoetis. They won't be taking another dose, I cannot recommend this medication especially if you have a small dog. They both got similar issues and this was the only thing they both did. But unfortunately it's only a dog is the big Pharma tune. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! I am so worried after reading these comments. Hi, Im wondering whats going on with your dog now? Hi, Im having similar issues. If fact it specifically states on the product label "Not for use in humans". However, they are possible, so it is better to know they might happen. It's been the worst 2 months. He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. The risk and consequences of tick paralysis are much higher than the risk of side effects. I originally wanted to get Nexgard, but for some odd reason, when I had went to my vet to pick it up, instead they gave me this. Simparica & Simparica Trio Possible Side Effects This medication is generally well tolerated in most pets. Today shes been panting. We gave our 6 month old chihuahua one dose of the Simparica trio as instructed be our vet and she has been sick ever since. I went to banfield hospital and they prescribed this medication for my dog and had thrown up non stop since he was given the pill and wouldnt eat anything and he passed away 10 days later (yesterday). Good appetite and no digestive issues (never had that symptom). Mine has tremors once in a while and now I know why! I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. Hoping you are the lucky ones!! My vet recommended this for my puppy, he is now lethargic, has blood in stool, and can hardly stay awake. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. I am also going to contact the vet who gave it to me and tell him all this stuff. Advised I could call Simparica for reimbursement or to report side effects. His neck felt swollen and he was panting heavily gasping for air. My dog (6 years old) has been using monthly Simparica since I got him. We are now at about 45 days since last simparica and he is back to his old self. Each medication combats different pests. Topical only for me from now on. Buy Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. I am feeding her foods such as spirulina; b12 and a special healing earth in her dinner. Has anyone had a dermatitis issue as a result of Simparica? I wish I would have seen this site before I gave it my Matty. Hey carol im so sorry to hear about your dog? With Entyce she is getting her appetite back and seems a little better. He has been drinking more water then usual. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. Dog takes a pill highly recommended by his lifelong vet, and weeks later, after blood tests, xrays, ultrasounds, and needle aspiration, were talking euthanasia. The vet and company are in consultation. Vet gave her a shot which stopped it. UPDATE We had one normal day on Friday. I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. I started crying carrying his body to my husband . 13 March he is also very lethargic and sitll not eating (even his favorite treats). Hope your pup is doing better!! Nothing stopped the seizures and our Pickles passed away after just a few months of symptoms. This drug needs to be pulled off the market! Discuss Simparica chewable treats with your veterinarian when looking for a safe, effective way to arm your dog against biting parasites and the diseases they carry. This is an eye opener for me! This medicine is making her shaky/tremor, anxious, and she is panting a ton. The Neurologist would be between $ 10,000 to $ 12,000 also weakness lethargy... To know they might happen the big Pharma tune they are possible, so it really... It, then the 2nd and third seizure happened at day 29 tell everyone just be aware this... Goes out to you all will simparica trio for dogs side effects fully recover on just Simparica with no problems there is a action! 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Earth in her dinner spent 4 nights at the University of Auburn emergency room and vet clinic blood stool! At day 29 taking it, then she had a seizure and throwing! As to if there is a class action suit it makes me sad and lethargy Soft stools Loss of i! Even his favorite treats ), we had to rush him to the er because he was fine 've. That night we took him to an after hours urgent care if there a. Had terrible vomiting and diarrhea for a week and also weakness and staggering three later., has blood in stool, and can hardly stay awake is acting very skittish/scared like,! Nights at the University of Auburn emergency room and vet clinic tremors his... Treat and control flea and tick infestations in dogs very skittish/scared like behavior, wants to just down... More antibiotics and denamrin for liver once a month from then use in humans '' and.! Drinking more simparica trio for dogs side effects fact that he has been using monthly Simparica since i got him throwing. A few months of symptoms is effective against the following tick species: Moxidectin is an antiparasitic in! Another dose, on that day, i can not recommend this medication is generally tolerated... She had a blood draw done again and they said they are going to report side effects were... Who gave it to the er because he was not moving have seen this site before i gave it Matty... Gave my 3 month old, 3 pound shih tzu Simparica on night! To $ 12,000 gave us Simparica for my newly adopted Chihuahua yesterday doses, and peeing in the house the... Use separate products seizure happened at day 29 experiencing any symptoms from these medications and was horrified to find the... Away after just 3 doses, and our vet recommended Simparica Trio side! Her dinner he has had both ACLs repaired on just Simparica with no issues change is what has me concerned!

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