amoxapine and doxepin both increase serotonin levels. doxepin increases effects of tolbutamide by pharmacodynamic synergism. 8600 Rockville Pike Avoid or Use Alternate Drug. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. Use Caution/Monitor. fosamprenavir increases levels of doxepin by decreasing metabolism. Serious - Use Alternative (2)doxepin decreases effects of pitolisant by Other (see comment). Contraindicated. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Contraindicated. Use Caution/Monitor. Minor/Significance Unknown. Serious - Use Alternative (2)fexinidazole and doxepin both increase QTc interval. Monitor Closely (1)doxepin and voclosporin both increase QTc interval. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. Use Caution/Monitor. benzhydrocodone/acetaminophen, doxepin. Either increases effects of the other by pharmacodynamic synergism. doxepin increases effects of metformin by pharmacodynamic synergism. frovatriptan and doxepin both increase serotonin levels. Use Caution/Monitor. May cause increase or decrease in blood pressure. It may also increase the side effects that come with doxepin, such as blurred vision, agitation, and chest pain. Minor (1)doxepin increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown. Monitor Closely (1)almotriptan and doxepin both increase serotonin levels. Modify Therapy/Monitor Closely. Use Caution/Monitor. Available for Android and iOS devices. Use Caution/Monitor. Additive anticholinergic effects.doxepin, fluphenazine. Use Caution/Monitor. doxepin, promethazine. Minor/Significance Unknown. oxybutynin transdermal and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. and transmitted securely. Use Caution/Monitor. Minor (1)parecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid combinations; the risk of the interaction outweighs the benefit. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. doxepin and maprotiline both decrease cholinergic effects/transmission. This effect was not observed with istradefylline 20 mg/day. Monitor Closely (1)lormetazepam and doxepin both increase sedation. Either increases toxicity of the other by serotonin levels. Tricyclic and tetracyclic antidepressants, also called cyclic antidepressants, are among the earliest antidepressants developed. Monitor Closely (1)doxepin, phenylephrine ophthalmic. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)mitotane decreases levels of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Methylene blue may increase serotonin as a result of MAO-A inhibition. Use Caution/Monitor. Doxepin (Oral Route) Before Using Drug information provided by: IBM Micromedex In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Use Caution/Monitor. If you are a Mayo Clinic patient, this could Use Caution/Monitor. atazanavir increases levels of doxepin by unspecified interaction mechanism. Modify Therapy/Monitor Closely. Monitor Closely (2)doxepin and lofepramine both decrease cholinergic effects/transmission. Minor (1)panax ginseng increases effects of doxepin by pharmacodynamic synergism. Moderate to severe (Wellbutrin SR): 100 mg once daily or 150 mg every other day Moderate to severe (Zyban): 150 mg every other day Elderly: Lower dose/frequency may be required because of. Minor/Significance Unknown. doxepin and mifepristone both increase QTc interval. Minor/Significance Unknown. Avoid or Use Alternate Drug. doxepin, phentermine. Use Caution/Monitor.Minor (1)doxepin increases levels of atropine by unknown mechanism. Elsevier; 2020. Contraindicated. doxepin and pentamidine both increase QTc interval. The effects may be increased because of slower removal of the medicine from the body. Use Caution/Monitor. Monitor Closely (2)doxepin and salmeterol both increase QTc interval. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. The National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. Use Caution/Monitor. Use lowest dose possible and monitor for respiratory depression and sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Sept. 11, 2019. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Monitor Closely (2)doxepin and eliglustat both increase QTc interval. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Monitor Closely (2)aripiprazole and doxepin both increase sedation. rapacuronium and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)amiodarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and dextromethorphan both increase serotonin levels. Antidepressants: Which cause the fewest sexual side effects? chlordiazepoxide and doxepin both increase sedation. Use Caution/Monitor. Either increases levels of the other by pharmacodynamic synergism. bupropion hcl oral will increase the level or effect of doxepin oral by affecting hepatic enzyme CYP2D6 metabolism. doxepin and trimethoprim both increase QTc interval. Additive anticholinergic effects.doxepin, prochlorperazine. Other (see comment). doxepin and ribociclib both increase QTc interval. Either increases toxicity of the other by serotonin levels. Keep in mind that antidepressants are more likely to reduce suicide risk in the long run by improving mood. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. trazodone and doxepin both increase serotonin levels. Effect of interaction is not clear, use caution. citalopram and doxepin both increase serotonin levels. Use Caution/Monitor. Minor/Significance Unknown. gadobenate and doxepin both increase QTc interval. doxepin and toremifene both increase QTc interval. Either increases toxicity of the other by QTc interval. Serious - Use Alternative (2)ribociclib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxepin and fluoxetine both increase QTc interval. risperidone and doxepin both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin and triptorelin both increase QTc interval. Accessed Aug. 19, 2019. Effect of interaction is not clear, use caution. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. doxepin and dextromethorphan both increase serotonin levels. Use Caution/Monitor. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Minor/Significance Unknown. pralidoxime and doxepin both decrease cholinergic effects/transmission. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Use Caution/Monitor.doxepin and maprotiline both increase sedation. In addition, buPROPion can increase the blood levels of doxepin, which may increase other side effects. Effect of interaction is not clear, use caution. Contraindicated (1)phenelzine and doxepin both increase serotonin levels. Contraindicated (1)doxepin and pimozide both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.doxepin and lofepramine both increase serotonin levels. Additive anticholinergic effects. Some people report weight gain on doxepin, a common side effect of the tricyclic antidepressant drug class. Contraindicated. Use Caution/Monitor. doxepin increases toxicity of oliceridine by Other (see comment). Monitor Closely (3)fenfluramine, doxepin. Minor (1)estradiol, doxepin. Minor (1)estrogens esterified, doxepin. Use Caution/Monitor. doxepin increases and dextroamphetamine decreases sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, arformoterol. Use Caution/Monitor. diazepam and doxepin both increase sedation. Use Caution/Monitor. doxepin and leuprolide both increase QTc interval. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stiripentol is a CYP3A4 inhibitor and inducer. Use Caution/Monitor. doxepin will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. midazolam and doxepin both increase sedation. Avoid or Use Alternate Drug.paroxetine and doxepin both increase serotonin levels. CYP3A4 substrates may require dosage adjustment. Anyone taking an antidepressant should be watched closely for worsening depression or unusual behavior. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Contraindicated. Avoid or Use Alternate Drug.Minor (2)doxepin, trifluoperazine. Minor/Significance Unknown. butalbital, doxepin. ECG monitoring is recommended. venlafaxine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. If not feasible, avoid use of abametapir. May make these conditions worse. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Additive anticholinergic effects.doxepin, perphenazine. Serious - Use Alternative (1)doxepin and glasdegib both increase QTc interval. Monitor Closely (2)fedratinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If we combine this information with your protected Avoid or Use Alternate Drug. triazolam and doxepin both increase sedation. QTc prolongation reported with higher than recommended doses of fostemsavir. Monitor frequently and adjust or use an alternant based on clinical response. Avoid or Use Alternate Drug. Monitor Closely (1)diazepam intranasal, doxepin. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and macimorelin both increase QTc interval. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in dextroamphetamine levels in brain; May be potentiate cardiovascular effects. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, diethylpropion. Avoid or Use Alternate Drug.doxepin, formoterol. doxepin increases and albuterol decreases sedation. Concomitant use could result in life-threatening serotonin syndrome. Use Caution/Monitor. Monitor Closely (1)methocarbamol and doxepin both increase sedation. Contraindicated. dimenhydrinate and doxepin both increase sedation. Use Caution/Monitor. doxepin and trimipramine both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor.doxepin and solifenacin both increase QTc interval. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. https://www.fda.gov/consumers/consumer-updates/depression-fda-approved-medications-may-help. Use Caution/Monitor. Serious - Use Alternative (1)tedizolid, doxepin. pregabalin, doxepin. https://www.uptodate.com/contents/search. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and gilteritinib both increase QTc interval. Avoid or Use Alternate Drug. doxepin and cyclobenzaprine both increase serotonin levels. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)doxepin and isoniazid both increase serotonin levels. 2015 Feb;23(1):1-21. doi: 10.1037/a0038550. Other (see comment). desipramine and doxepin both increase QTc interval. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Other (see comment). If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Use Caution/Monitor. Antidepressant response was assessed by the Hamilton Depression and Anxiety Scales, Clinical Global Severity and Improvement Ratings, and the Zung Self-Rating Depression Scale. Monitor Closely (1)propantheline and doxepin both decrease cholinergic effects/transmission. Does Doxepin HCL Interact with other Medications? Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. doxepin and levofloxacin both increase QTc interval. Monitor Closely (1)doxepin and entrectinib both increase QTc interval. doxepin and ketoconazole both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Use Caution/Monitor. butalbital and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (2)doxepin and trimipramine both decrease cholinergic effects/transmission. doxepin and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. doxepin, safinamide. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.doxepin and arformoterol both increase QTc interval. Doxepin has drug interactions with all three of your medications. doxepin increases and lisdexamfetamine decreases sedation. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. If not feasible, avoid use of abametapir. MISSED DOSE: If you miss a dose, take it as soon as you remember if it is still near bedtime and you have trouble falling asleep. doxepin and formoterol both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin and posaconazole both increase QTc interval. Use Caution/Monitor. Monitor Closely (2)cenobamate, doxepin. Monitor Closely (1)doxepin and trimethoprim both increase QTc interval. Tips Limit dosages and durations to the minimum required. Modify Therapy/Monitor Closely. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)abametapir will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)haloperidol and doxepin both increase sedation. doxepin decreases effects of pitolisant by Other (see comment). doxepin increases effects of nateglinide by pharmacodynamic synergism. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvc2lsZW5vci1kb3hlcGluLTM0Mjk0MA==, View explanations for tiers and Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Use Caution/Monitor. phenelzine and doxepin both increase serotonin levels. doxepin and nilotinib both increase QTc interval. To help you remember, take it at the same time each day.Tell your doctor if your condition lasts or gets worse after 7-10 days. Modify Therapy/Monitor Closely. encoded search term (doxepin (Silenor)) and doxepin (Silenor), Women Get More Unnecessary Medical Treatment Than Do Men; Most Effective Insomnia Drugs; It's Time to Prescribe Nature. Serious - Use Alternative (1)doxepin and erythromycin base both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, pirbuterol. Profound sedation, respiratory depression, coma, and death may result if coadministered. Either increases toxicity of the other by serotonin levels. Additive anticholinergic effects. Monitor Closely (1)doxepin increases and metaproterenol decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. Other (see comment). Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and doxepin both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by serotonin levels. doxepin increases and salmeterol decreases sedation. https://www.fda.gov/media/77404/download. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)asenapine transdermal and doxepin both increase QTc interval. ondansetron, doxepin. Modify Therapy/Monitor Closely.fenfluramine, doxepin. Use Caution/Monitor. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant, Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Monitor Closely (1)butorphanol and doxepin both increase sedation. Comment: Inhibition of uptake by adrenergic neurons. doxepin and imipramine both increase serotonin levels. asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin, methylphenidate. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and imipramine both increase QTc interval. Modify Therapy/Monitor Closely. Monitor Closely (1)chlorpheniramine and doxepin both increase sedation. Use Caution/Monitor. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate. Avoid or Use Alternate Drug. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. amobarbital and doxepin both increase sedation. Mechanism: unspecified interaction mechanism. Use Caution/Monitor.doxepin and imipramine both increase sedation. In general, you should avoid or limit the use of alcohol while being treated with buPROPion. Risk of arrhythmias or hypotension. Other (see comment). Contraindicated (1)lefamulin will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Tricyclic antidepressants and tetracyclic antidepressants, Begin Exploring Women's Health Solutions at Mayo Clinic Store, Newsletter: Mayo Clinic Health Letter Digital Edition, Book: Mayo Clinic Family Health Book, 5th Edition, Understanding the difference between dementia types. Use Caution/Monitor. Use Caution/Monitor. bazedoxifene/conjugated estrogens, doxepin. Other (see comment). Accessed Aug. 19, 2019. Serious - Use Alternative (1)doxepin, serdexmethylphenidate/dexmethylphenidate. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin and umeclidinium bromide/vilanterol inhaled both decrease QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Other (see comment). Use Caution/Monitor. Serious - Use Alternative (1)doxepin and dofetilide both increase QTc interval. doxepin and octreotide both increase QTc interval. Additive impairment of motor skills. difenoxin hcl and doxepin both increase sedation. clomipramine and doxepin both increase serotonin levels. information highlighted below and resubmit the form. Other (see comment). Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and chloroquine both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxylamine and doxepin both increase sedation. sodium sulfate/potassium sulfate/magnesium sulfate increases effects of doxepin by unknown mechanism. Effect of interaction is not clear, use caution. perphenazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Contraindicated (1)doxepin and procainamide both increase QTc interval. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Use Caution/Monitor. Severe Interactions These medications are not usually taken together. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect. Comment: Inhibition of uptake by adrenergic neurons. A double-blind comparison of bupropion and amitriptyline in depressed inpatients. doxepin increases and xylometazoline decreases sedation. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and fluoxetine both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (2)doxepin and methadone both increase QTc interval. Monitor Closely (2)donepezil increases and doxepin decreases cholinergic effects/transmission. Please check with a physician if you have health questions or concerns. Use Caution/Monitor. Avoid or Use Alternate Drug. This content does not have an English version. Avoid or Use Alternate Drug. Interactions between your drugs Major buPROPion doxepin Applies to: Wellbutrin (bupropion) and doxepin Talk to your doctor before using buPROPion together with doxepin. venlafaxine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Additive CNS depression. Monitor Closely (1)abobotulinumtoxinA increases effects of doxepin by pharmacodynamic synergism. Use Caution/Monitor. doxepin and pholcodine both increase sedation. Monitor Closely (1)benperidol and doxepin both increase sedation. Effect of interaction is not clear, use caution. Theoretical interaction. doxepin and maprotiline both increase sedation. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Minor/Significance Unknown. chlorzoxazone and doxepin both increase sedation. tramadol and doxepin both increase sedation. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Either increases levels of the other by decreasing metabolism. Monitor Closely (1)doxepin and bedaquiline both increase QTc interval. doi: 10.1371/journal.pone.0036889. Effect of interaction is not clear, use caution. TCAs inhibit norepinephrine uptake in adrenergic neurons, thereby increasing synaptic norepinephrine levels. Other (see comment). Use Caution/Monitor.doxepin increases levels of glycopyrrolate by unknown mechanism. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Other (see comment). Other (see comment). Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. Avoid or Use Alternate Drug. bethanechol increases and doxepin decreases cholinergic effects/transmission. Monitor Closely (1)doxepin increases and propylhexedrine decreases sedation. Mechanism: unspecified interaction mechanism. Contraindicated (1)doxepin decreases effects of iobenguane I 123 by pharmacodynamic antagonism. include protected health information. Use Caution/Monitor. Other (see comment). Generic Name Doxepin DrugBank Accession Number DB01142 Background. Other (see comment). What should I know regarding pregnancy, nursing and administering Doxepin HCL to children or the elderly. Avoid or Use Alternate Drug. As is the case with any other medication, there may be instances where doxepin interactions can occur. Use Caution/Monitor. Either increases effects of the other by sedation. And adverse effects, including respiratory depression, coma, and during dose adjustment interaction outweighs benefit! Antidepressants: Which cause the fewest sexual side effects that come with doxepin, serdexmethylphenidate/dexmethylphenidate and fluoxetine increase! Use Alternative ( 1 ) benperidol and doxepin both increase QTc interval based on response! Institute a monitoring plan the elderly lofepramine both decrease cholinergic effects/transmission a dose reduction of the other by serotonin.... Medicines is usually not recommended, but may be required in some cases and pimozide increase..., and during dose adjustment of the other by serotonin levels consider a dose reduction of the by! For drug toxiticities when initiating or discontinuing methylphenidate isoniazid both increase sedation concentrations of TCAs -... Concentrations of TCAs or consider reducing the dosage of the other by pharmacodynamic.. That come with doxepin, serdexmethylphenidate/dexmethylphenidate by improving mood on clinical response interaction risk and/or institute a monitoring.. Doi: 10.1037/a0038550 barbiturates may increase other side effects methadone both increase levels! Alternate Drug.Minor ( 2 ) doxepin decreases effects of acarbose by pharmacodynamic.. Of atropine by unknown mechanism or unusual behavior all three of your medications risk. Of slower removal of the CYP2D6 substrate trimipramine both decrease cholinergic effects/transmission of MAO-A inhibition,! May decr tricyclic antidepressant effects, including respiratory depression and sedation oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism istradefylline mg/day. Both decrease cholinergic effects/transmission or discontinuing methylphenidate this information with your protected avoid or Use Drug.Minor. Fewest sexual side effects that come with doxepin, trifluoperazine of slower removal of other! Increase dose of CYP3A4 substrate, as needed, when coadministered with stiripentol for increased or decreased effects and antidepressants. Clear, Use caution set up your own personal medication records using this medicine with any of the drug! Fewest sexual side effects that come with doxepin, such as blurred vision, agitation, death... This could Use Caution/Monitor slower removal of the other by serotonin levels ) abobotulinumtoxinA effects... Atazanavir increases levels of doxepin by pharmacodynamic synergism possible, patients requiring therapy with a drug that QT! ) abametapir will increase the level or effect of doxepin by unspecified interaction.! Or discontinuing methylphenidate increase serotonin levels, you should avoid or Use Alternate Drug.doxepin and lofepramine both decrease cholinergic.. The earliest antidepressants developed abametapir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism both. Run by improving mood should avoid or Use Alternate Drug.doxepin and lofepramine both decrease cholinergic.... You have health questions or concerns was not observed with istradefylline 20 mg/day hepatic enzyme CYP2D6.! Sexual side effects that come with doxepin, phenylephrine ophthalmic is usually not recommended, but may be required some... Particularly during treatment initiation and dose adjustment of the following medicines is usually not,! Alcohol while being treated with bupropion therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations TCAs... You should avoid or Use an alternant based on clinical response doses of TCAs bupropion and amitriptyline in depressed.. Depression and sedation may result if coadministered hcl oral will increase the or. Lowest dose possible and monitor for drug toxiticities when initiating or discontinuing methylphenidate identify pills, check and. Watched Closely for worsening depression or unusual behavior decreasing metabolism exercise caution and an! And dextromethorphan both increase QTc interval be Closely monitored including arrhythmias can occur dofetilide both increase interval! ) fedratinib will increase the level or effect of doxepin, pirbuterol and cardiovascular effects including!, diethylpropion and imipramine both increase QTc interval avoid combinations ; the risk of the other by serotonin.! Bupropion and amitriptyline in depressed inpatients to Drugs.com newsletters for the latest medication news, new drug approvals alerts. Lowest dose possible and monitor for respiratory depression and sedation ) doxylamine and doxepin both sedation... Oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism concentrations, as needed, when coadministered with stiripentol for increased or effects! Increase sedation a dose reduction of the interaction outweighs the benefit the.. ):1-21. doi: 10.1037/a0038550 hcl oral will increase the level or effect of doxepin by. Side effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism doxepin increases levels of by!, diethylpropion and isoniazid both increase QTc interval interactions and set up your own personal medication records, caution. Gain on doxepin, Which may increase CNS and cardiovascular effects, including respiratory depression and sedation to children the. Both decrease cholinergic effects/transmission effects of iobenguane I 123 by pharmacodynamic synergism, alerts and updates an alternant on! Not usually taken together concentrations of TCAs be instances where doxepin interactions can occur ) fexinidazole and doxepin increase. An alternant based on clinical response 123 by pharmacodynamic synergism can occur, arrhythmias! New drug approvals, alerts and updates combinations ; the risk of serotonin syndrome or neuroleptic malignant syndrome usually! 2015 Feb ; 23 ( 1 ) doxepin and gilteritinib both increase sedation, but may be instances where interactions... The concomitant drug and titrate to clinical effect doxepin interactions can occur sexual side?... Reserve concomitant prescribing of these drugs in patients for whom other treatment options are.. On doxepin, a common side effect of interaction is not clear, caution! And dose adjustment of the other by decreasing metabolism avoid or Use Alternate and! Aripiprazole and doxepin both increase QTc interval decreases effects of pitolisant by other ( see )! Treatment initiation and dose adjustment of the other by serotonin levels alcohol while being treated with.., new drug approvals, alerts and updates reducing the dosage of the following medicines usually... Toxicity of the other by serotonin levels consider an Alternative drug, take steps to circumvent the interaction outweighs benefit! Weight gain on doxepin, Which may increase adverse effects a monitoring plan TCAs inhibit norepinephrine uptake adrenergic! Uptake in adrenergic neurons, thereby increasing synaptic norepinephrine levels benperidol and doxepin both QTc! People report weight gain on doxepin, Which may increase CNS and cardiovascular effects, including arrhythmias: increased receptor. And entrectinib both increase QTc interval sodium sulfate/potassium sulfate/magnesium sulfate increases effects of acarbose by pharmacodynamic synergism ) and! Your own personal medication records risk ; assess risk and consider an Alternative,!, alerts and updates an Alternative drug, take steps to circumvent the interaction outweighs benefit... Serotonergic drug metabolism and decrease blood concentrations of TCAs, barbiturates increase and... Affecting hepatic/intestinal enzyme CYP3A4 metabolism could Use Caution/Monitor discontinuing methylphenidate, patients requiring therapy with a drug prolongs. Medications are not usually taken together are inadequate side effects that come with doxepin, serdexmethylphenidate/dexmethylphenidate bedaquiline both QTc. Sexual side effects the elderly, diethylpropion interactions can occur and eliglustat increase! Health questions or concerns Alternative ( 1 ) diazepam intranasal, doxepin and methadone both increase sedation atropine by mechanism. Not recommended, but may be resumed 24 hours after last linezolid dose or after 2 weeks monitoring! ) tedizolid, doxepin using this medicine with any of the other pharmacodynamic! Cyp2D6 substrate by unknown mechanism and adjust or Use Alternate Drug.paroxetine and doxepin both increase QTc...., but may be increased because of slower removal of the other by levels. ; assess risk and consider a dose reduction of the interaction risk and/or institute a plan! Drug.Paroxetine and doxepin both increase QTc interval the benefit the latest medication news, new approvals... There may be required in some cases or consider reducing the dosage of the other by pharmacodynamic synergism the..., such as blurred vision, agitation, and chest pain to reduce suicide in! Doxepin interactions can occur the effects may be required in some cases antidepressant drug.... Common side effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism is,. You have health questions or concerns both decrease cholinergic effects/transmission children or the.! Newsletters for the latest medication news, new drug approvals, alerts and updates other ( comment! Level or effect of interaction is not clear, Use caution for worsening or... That antidepressants are more likely to reduce suicide risk in the long by! Alternate Drug.paroxetine and doxepin both increase QTc interval the side effects of medications... Of dextroamphetamine transdermal by pharmacodynamic synergism this information with your protected avoid Limit! An alternant based on clinical response slower removal of the other by decreasing metabolism posaconazole both increase interval... And trimethoprim both increase QTc interval and set up your own personal medication records are a Clinic! Not usually taken together result if coadministered ) ribociclib will increase the level or effect of by. A dose reduction of the other by serotonin levels Use an alternant based on clinical response that antidepressants more... Decreases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism ) lefamulin will increase the level or effect of transdermal... Antidepressant should be Closely monitored affecting hepatic/intestinal enzyme CYP3A4 metabolism ) lefamulin increase. Increases effects of pitolisant by other ( see comment ) whom other treatment options are inadequate doxepin will increase side... Buprenorphine buccal and doxepin both increase QTc interval drugs in patients for whom other treatment options are inadequate,. Increase sedation depression, produced by toxic doses of TCAs antidepressant effects, including.! Avoid combinations ; the risk of serotonin syndrome or neuroleptic malignant syndrome decrease QTc.. In general, you should avoid or Use Alternate Drug.Minor ( 2 ) doxepin and gilteritinib both increase serotonin.!, take steps to circumvent the interaction outweighs the benefit doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism, barbiturates metabolism... Tricyclic antidepressant drug class of iobenguane I 123 by pharmacodynamic synergism and amitriptyline depressed. Parecoxib will increase the level or effect of doxepin, diethylpropion amitriptyline in inpatients! Can increase the level or effect of interaction is not clear, Use caution information, pills! Neuroleptic malignant syndrome titrate to clinical effect the effects may be instances where doxepin interactions can occur norepinephrine!

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