Diffuse large B-cell lymphoma and mantle cell lymphoma of the ocular adnexal region, and lymphoma of the lacrimal gland: an investigation of clinical and histopathological features. 1970 Dec;8(3):413-24. The data used and/or analysed during the current study are available from the corresponding author on reasonable request. Mod Pathol. The other two cases were mantle cell lymphoma (MCL) and peripheral T cell lymphoma, not otherwise specified (PTCL, NOS). 353358, 2001. While the etiology is poorly understood, a number of previous theories exist, which are included here in the context of a literature review. Saxman S, Righi P. Mantle cell lymphoma appearing as a tongue base mass. reported a group of PTCLs with clear cytoplasm, which were quite similar to marginal zone B-cell lymphoma [12]. When on the surface tissue, there may be a yellow, white, or even vesicular appearance, as seen in Figure 1. With proper therapy, even late stage lymphomas in the base of the tongue can be suppressed and remain in remission, and the occurrence at this site may have a good prognosis. e. Tumour cells were positive for CD4 (200x). In addition, patients may notice irregularities on their own, thereby bringing the appearance to the attention of their dentists or hygienists. Article 2000;113:5128. Follicular lymphoid hyperplasia (FLH) is a benign lymphoproliferative process of unknown etiology, uncommon in the head and neck region. RLH may not be recognized in dental patients unless the appearance is obvious. 2013 Dec;137(12):1837-42. doi: 10.5858/arpa.2012-0678-RS. a. H&E showed a diffuse infiltrate of large cells with an obvious nucleolus and abundant cytoplasm (200 x). .. 1991 Jul;86(7):801-8. Ren, X., Cheng, Y., Wu, S. et al. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Formalin-fixed, paraffin-embedded tissue blocks of enrolled cases were used to make three-micrometer-thick sections. Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. The biopsy showed recurrence, with bone marrow involvement. Jrvenp P, Ilmarinen T, Geneid A, Pietarinen P, Kinnari TJ, Rihkanen H, Ruohoalho J, Markkanen-Leppnen M, Bck L, Arkkila P, Aaltonen LM. For NHL of the head and neck, there is a logarithmic increase in incidence with increasing age [18] .The average age at disease diagnosis was 61.8years and there were no observed gender differences. official website and that any information you provide is encrypted All these factors might explain why the patient survived only 3months after diagnosis although he was in an early stage and had a low IPI score. statement and PMC The HPV ISH positive case also had diffuse and strong expression of P16 protein as revealed by IHC, besides, HPV RNA ISH in this case is negative (Fig. No progression to malignancy has been reported, although one multisite case within the oral cavity was found to represent MALT-type lymphoma [1]. The biological behaviours that are exclusive to the tongue base are not clear. Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. Springerplus. Bookshelf Surgical debulking/excision is the treatment of choice. Extranodal NHL is complicated; it consists of a group of tumours with different pathological, clinical and prognostic characteristics [6] .Existing series presenting extranodal NHL have mainly summarized the tumours that occur in the head and neck but are not specific to the base of the tongue. J Postgrad Med. M. Samoszuk, E. Ramzi, and J. Ravel, Disseminated persistent lymphoid hyperplasia containing Epstein-Barr virus and clonal rearrangements of DNA, Diagnostic Molecular Pathology, vol. 2017 Feb;274(2):931-937. doi: 10.1007/s00405-016-4307-8. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). Tumours in this site are predominantly DLBCL subtypes in histology. 172175, 2003. https://doi.org/10.1093/jnci/djn011. https://doi.org/10.1002/ajh.23176. A clinical note. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. From: The Teaching Files: Chest, 2010 View all Topics Most DLBCL cases of the tongue base had no Bcl-2, Bcl-6, or c-Myc rearrangement and they were sensitive to rituximab. Written informed consent was obtained from each patient. These tissues act as your body's first line of defense against infections. Nancy W. Burkhart, EdD, BSDH, AFAAOM, is an adjunct associate professor in the Department of Periodontics-Stomatology, College of Dentistry, Texas A&M University, Dallas, Texas. https://doi.org/10.1017/s0022215100142288. Expression and alteration of p16 in diffuse large B cell lymphoma. For the in situ detection of high-risk HPV integration at the mRNA level, the RNAscope FFPE 2.5 HD detection kit (Brown) (CAT #322310) was used according to the manufacturers instructions. Extranodal lymphomas of the head and neck. Her chemotherapy regimen was changed to GDP. The exceptional case here was a 45-year-old male patient with diffuse large B cell lymphoma who presented with only deep painful mouth ulcers and general symptoms, including sore throat, choking when drinking water, and difficulty swallowing. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. Domanski HA, Akerman M. Fine-needle aspiration cytology of tongue swellings: a study of 75 cases. https://doi.org/10.4103/0019-509X.58873. She is founder and cohost of the International Oral Lichen Planus Support Group (dentistry.tamhsc.edu/olp) and coauthor of General and Oral Pathology for the Dental Hygienist, now in its third edition. The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. Virchows Arch. Benign Lymphoid Hyperplasia of the Tongue Base Causing Upper Airway Obstruction Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. The airway was subsequently secured, and the procedure was undertaken. 2006;45:25871. Mod Pathol. https://doi.org/10.11406/rinketsu.58.2033. Squamous cells also make up the top layer of skin and other body parts such as the lungs and esophagus. 39, no. Google Scholar. It is composed of cortex and medulla. Jain KS, Sikora AG, Baxi SS, Morris LG. 2, pp. Imaging and pathological findings of MCL (case 2). 2005;9:34050. Six of the cases exhibited tongue base masses with smooth surface membranes. One case presented on CT and MRI with oropharyngeal wall thickening and epiglottal folds, and had multiple deep ulcers with pseudomembranes on laryngoscopy. Does lymphoid hyperplasia and Lymphoma looks the same and is there a threatment for oral Lymphoid Hyperplasia? Paraffin sections were prepared according to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol. Terms and Conditions, Diagn Pathol 15, 30 (2020). Of the 6 B-cell NHL cases, 5 were DLBCLs and 1 was MCL. e. Tumour cells were positive for Cyclin D1 (200x). His IPI score was 2(low to intermediate risk group). Sun J, Zhang J, Ling Q, Luo Y, Wu S, Liang Z, Zhong D, Zeng X. PET-CT/CT/MRI scans of the cancerous areas were reviewed to assess the extension of the lesions, including to the bone and thorax. https://doi.org/10.1186/s13000-020-00936-w, DOI: https://doi.org/10.1186/s13000-020-00936-w. Cut-off values were set as previously described [9]. Please review the contents of the article and, 10.1002/1097-0142(196909)24:3<487::aid-cncr2820240310>3.0.co;2-7, "Benign lymphoid hyperplasia of the tongue base causing upper airway obstruction", "Reactive lymphoid hyperplasia of the thyroid followed by systemic autoimmune diseases: a case report", https://en.wikipedia.org/w/index.php?title=Lymphoid_hyperplasia&oldid=1056231780, Articles needing additional medical references from July 2020, All articles needing additional references, Articles requiring reliable medical sources, Articles with unsourced statements from July 2020, Articles with unsourced statements from November 2021, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 20 November 2021, at 15:19. government site. b. Tumour cells diffusely expressed CD20 (200 x). Two patients, including our patient, died during follow-up. A mass was identified in the right base of the tongue that caused breathing difficulties. Lopez-Guillermo et al. Careers. Vocal cord involvement can cause choking. CAS Harabuchi Y, Tsubota H, Ohguro S, Himi T, Asakura K, Kataura A, Ohuchi A, Hareyama M. Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring. On this Wikipedia the language links are at the top of the page across from the article title. The obstructive lesion was biopsied, and specimens were sent fresh for lymphoma histopathology protocol. Positive staining was indicated by brown punctate dots in the cytoplasm. She can be contacted at nburkhart@tamhsc.edu. I am taking medicine nd it is reducing but its been 3 weeks now? Hi, my biopsy says reactive lymphoid hyperplasia, does it means it is benign? Please enable it to take advantage of the complete set of features! Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Others theorize that it is caused by compensatory lymphoid hyperplasia after an adenotonsillectomy.19,20 Hypertrophied lymphoid follicles in the lingual tonsils of adults has been previously associated with the signs and symptoms of GERD.10 Mamede et al9 have suggested a possible link between the hypertrophy of the base of tongue and . Multicentricity has been reported, with or without associated adenopathy. 2000;21:2716. The site is secure. https://www.linkedin.com/showcase/4000114/. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. External beam radiation has been successful in a single case [6]. Rinsho Ketsueki. 2012;28:43541. Cytoplasmic composition also varied between cases, from abundant to scant. 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